PolyPhen-2 report for P08294 A91T (rs17879876)

Query

Protein Acc	Position	AA₁	AA₂	Description
P08294	91	A	T	Canonical; RecName: Full=Extracellular superoxide dismutase [Cu-Zn]; Short=EC-SOD; EC=1.15.1.1; Flags: Precursor; Length: 240

Results

Prediction/Confidence

PolyPhen-2 v2.2.2r398

HumDiv

This mutation is predicted to be benign with a score of 0.389 (sensitivity: 0.90; specificity: 0.89)

Confidence

HumVar

Details

Multiple sequence alignment

UniProtKB/UniRef100 Release 2011_12 (14-Dec-2011)

QUERY	DDGALHAACQVQPSATL-DAAQPRVTGVVLFRQLAPR	A	KLDAFFALEGFPTEP-NSS-------------------
sp\|F7H9D9#1	GDGALHAACQVQPSATL-DAAQPRVTGVVLFRQLAPR	A	KLEAFFALEGFPTQP-NNS-------------------
sp\|F7FQX5#1	DDDALHATCQVQPSATL-DAAQPRVTGVVLFRQLAPR	A	KLEAFFDLEGFPAEP-NSS-------------------
sp\|P41975#1	PAGALHAVCRVQPSATL-DAAQPRVSGLVVFRQLGPG	A	QLEAFFDLEGFPVEA-NLS-------------------
sp\|A3KLR9#1	PDAALHAVCRVLPSATL-EAEQPRVSGLVLFRQLRPG	A	LLEAFFHLEGFPNEP-NGT-------------------
sp\|Q007T6#1	QEAALHATCSMQPSVLL-DAAQPQVTGLVLFRQLRPG	A	LLEAFFHLKGFPAEP-NST-------------------
sp\|G3TMG2#1	PGADLYTACSVQPSASI-GAAQPRVTGLVLFRQLAPG	A	KLEAFLDLEGFTAEH-NGS-------------------
sp\|B2CZE9#1	PDAALHAVCRVLPSATL-EAEQPRVSGLVLFRQLRPG	A	LLEAFFHLEGFPNEP-NGT-------------------
sp\|UPI0000F64D30#1	PNAALHAVCRVQPSATL-DAKQPRVTGLVLFRQSAPE	A	RLEAFFDLEGFPEES-NNS-------------------
sp\|UPI00005A0592#1	PGSALHAACRVQPSASL-DPAQPRVSGLVLFRQPAPG	A	PLEAFFHLDGFPAER-NGS-------------------
sp\|F1PAS8#1	--SALHAACRVQPSASL-DPAQPRVSGLVLFRQPAPG	A	PLEAFFHLDGFPAER-NGS-------------------
sp\|Q33DP1#1	EATEMHAICQVQPSASL-ASDQPRVTGLVLFKQLSPS	S	RLEAFFDLEGFPAEP-NAS-------------------
sp\|G1PZI4#1	EATVLYAACHVQPSASL-DTTEPQVTGLVLFRQLAPG	G	RLDAYFDLKGFPSEP-NIS-------------------
sp\|G3ID79#1	DATEMYAICQVQPSASL-ATDQPRVTGLVLFKQLSPS	S	RLEAFFDLEGFPAQP-KAS-------------------
sp\|Q08420#1	DAREMHAVCRVQPSAML-PPDQPQITGLVLFRQLGPS	S	RLEASFNLEGFPAEQ-NTS-------------------
sp\|Q64466#1	DAAEMHAICRVQPSATL-PPDQPQITGLVLFRQLGPG	S	RLEAYFSLEGFPAEQ-NAS-------------------
sp\|O09164#1	DAAEMHAICRVQPSATL-PPDQPQITGLVLFRQLGPG	S	RLEAYFSLEGFPAEQ-NAS-------------------
sp\|O88592#1	DAAEMHAICRVQPSATL-PPDQPQITGLVLFRQLGPG	S	RLEAYFSLEGFPAEQ-NAS-------------------
sp\|Q3UM12#1	DAAEMHAICRVQPSATL-PPDQPQITGLVLFRQLGPG	S	RLEAYFSLEGFPAEQ-NAS-------------------
sp\|F6UAR4#1	DDHIVYATCQVQPSSTL-EANKPQVTGQVLFKQLYPD	G	KMEVFFDLQGFPADTRNAT-------------------
sp\|UPI000223E5E1#1	DEDPVYAACEVKPSSIL-EADQPRVTGRVLFRQQYPD	G	RLEAIFDLNGFPTVG-NGT-------------------
sp\|G3W9F8#1	DEHTVYATCQVKPSSTL-EAGKPQVTGQVLFKQLYPN	G	KMDVFFDLEGFPANTRNTS-------------------
sp\|A9JTW5#1	NDGIAYATCSLSPSSKL-EPSEVKVTGLVLFKQVFPS	G	TLEAIFDLEGFPTDA-NQS-------------------
sp\|G1K8G8#1	SNGTAYAVCTVKPSTKL-DAGMPQVTGQVLFRQTYPY	G	KLESIFYLDGFPTGA-NLS-------------------
sp\|UPI0000E8048A#1	TDGLTYATCEVKPSSKI-DADKPQVTGQVLFRQHYSQ	G	KLEAIFHLDGFPLDN-NQS-------------------
sp\|G5BE34#1	PDVGLHAVCHMQPSATL-DAEQPRVSGLVLFRQPGPG	A	RLEAFFDLEGFPEEA-NSS-------------------
sp\|UPI0001C9C255#1	TDGLTYATCEMKPSSKI-GADKPQVTGQVLFRQHYSQ	G	RLEAIFHLDGFPLDN-NQS-------------------
sp\|G1NIN0#1	TDGLTYATCEMKPSSKI-GADKPQVTGQVLFRQHYSQ	G	RLEAIFHLDGFPLDN-NQS-------------------
sp\|UPI000194C39C#1	TDGMIYATCEMKPSSKI-DADKPQVTGQVLFRQSYSY	G	RLEALFYLDGFPLDN-NQS-------------------
sp\|F1NHI4#1	-----YATCEVKPSSKI-DADKPQVTGQVLFRQHYSQ	G	KLEAIFHLDGFPLDN-NQS-------------------
sp\|E9QIM2#1	---SLQAVCRMQPNTRL-EPGMPRVYGHILFRQSGPK	E	KLSVTFRLYGLPADS--QQ-------------------
sp\|B8JKE9#1	---SLQAVCRMQPNTRL-APGMPRVYGHILFRQSGPK	E	KLSVTFRLYGLPADS--QQ-------------------
sp\|G1LPB6#1	-------QAAADXSATL-DTAQPRVSGLVLFRQLAPG	A	RLEAFFDLEGFPAEA-NSS-------------------
sp\|UPI00017B4836#1	NNGSLYAACNMRPSALL-PEDLPKVHGHVLFKQDHPQ	G	GLSALLQLGGFLSDG---E-------------------
sp\|UPI00022B401A#1	NNGTLYAVCKVRPSTSL-PEDLPKVYGHVLFKQDHPQ	E	KVKVLLRFSGFPRDG-SPE-------------------
sp\|B5X798#1	---TVYAACKMRPSTKL-GEGLPNVYGQVLFKQEYPE	G	SLKVLFLLHGFPSHS-DHQ-------------------
sp\|F1R0Y7#1	-NNTIYATCEVSPIPNL-PAGQPEIFGQVLFRQVFPN	G	TAEVKINLRGFPETD--NQ-------------------
sp\|A5PLA4#1	-NNTIYATCEVSPIPNL-PAGQPKIFGQVLFRQVFPN	G	TAEVKINLRGFPETD--NQ-------------------
sp\|G3Q125#1	-NGTLYAACKMRPSTSL-ADGLPKVYGQVLLKQDYPL	G	KLNALLRFNGFPSEG-DPQ-------------------
sp\|Q4S6J6#1	--------CNMRPSALL-PEDLPKVHGHVLFKQDHPQ	G	GLSALLQLGGFLSDG---E-------------------
sp\|D2I2A5#1	--------------------AKPRVSGLVLFRQLAPG	A	RLEAFFDLEGFPAEA-NSS-------------------
sp\|Q5GR13#1	-DEYMYARCEMGMNPVM-ANTPHNIQGTIFLRQK-IY	Q	PLEVLLHLKGFDVPAGDHDHSGHAAHMGHTHHTDHTGH
sp\|Q8I806#1	------AMCYMKPNPVLPDTIDTKVTGTVMLSQKSPS	A	KIKITLNLKGLPPNT-----------------------
sp\|UPI0001CBB87A#1	-VYAGCSLRANPVQNID-PDINRPIEGYIEARQLISG	G	VVDITLDLSGFNSNS-----------------------
sp\|UPI0001CBB879#1	-IHAGCYLRPNPSLNSN-DEIYRPIEGSIHVKQLTSG	G	DVEISLDVSGFDSRA-----------------------
sp\|UPI0001CBA0DE#1	-------------------------------------	-	-------LEGLSAHS-----------------------
sp\|G3MQI9#1	----------------------GPVFMQLFFVQESIE	H	SVVITGDITGLQP-G-----------------------
sp\|UPI0001CBB87A#2	-IHAGCYLRPNPSLNSN-DEIYRPIEGSIHVKQLSTG	G	EVEITLDLSGFDSNS-----------------------
sp\|UPI0001CBB87B#1	YIYAGCYMTPDPALEKD-AALYKPIEGTISVKQRSTG	G	NIDIILDLSGFDASS-----------------------
sp\|B7QH32#1	------------------VLNAGEIRGIVQFAQL-NA	S	HVRVSFNGSGIPE-G-----------------------
sp\|E7CQT9#1	---GLHSTCELAPDA---EGGPDGVSGTLDFLQKTER	D	PVHVTGAVYGLTP-G-----------------------
sp\|B7PEF3#1	-----DEDVTDAICKLT-QPAGGNLTGVLSFQQNDPE	D	LVTIIGDISGLSP-G-----------------------
sp\|G4XHW2#1	------------------------VTGTLTLEQLRPT	S	PVLINGVIYGLTE-G-----------------------
sp\|E0VY69#1	------------------------LTGDVIFRQTNPE	D	PVEITGVISGLSP-G-----------------------
sp\|D6X0S3#1	---------------------------IVFFQRHPPN	G	PILVRGNLTDLPP-G-----------------------
sp\|Q90023#1	----------TKPVSAI-AVLEGPVKGTVRFVE--ES	S	KVKISVDISGLKPNR-----------------------
sp\|C5KTS7#1	GSLFPIFPIRASANLVA-RESRSPARGIFYFEQV-GH	A	RTKITYDVSNLEPGS-----------------------
sp\|D2DSH2#1	----------YAECVLK-ASSKSNVTGTLSLVQSRSF	L	PVLITGNITGLSE-G-----------------------
sp\|B7QEW8#1	-------------------------------------	-	-LNVHVHVTGFKVNASARDHRAY---------------
sp\|E9FXW0#1	------AVCEMKPNKAL-QRTKHNIVGKVAFTQT-TG	G	PLNVHVNLRGLRTNGKS---------------------
sp\|G0MK39#1	-----------------------ELIGTIDFDQ--SG	S	FLKLNGSVSGLPA-G-----------------------
sp\|G4M0N2#1	--------------------VTPPYSGTVYFTK--HG	S	NLRVTGSVSGLPPKK-----------------------
sp\|B6HFF6#1	-------------------------------------	-	--------------------------------------
sp\|E3TD71#1	---------NVKNGIVL-MTANPNYSGQVFMRTNSDG	M	TSSLLGNVTGFTPNS-----------------------
sp\|F5GTG7#1	-------------------------------------	-	-------VSGLPV-G-----------------------
sp\|A7L9U0#1	------------------DGDPQKLIGIIDFVQ--YR	S	LVKLNGTVSGLKP-G-----------------------
sp\|Q53CP2#1	------------------DGDPQKLIGIIDFVQ--YR	S	LVKLNGTVSGLKS-G-----------------------
sp\|E2BYV3#1	-------------------------------------	-	-----------NP-G-----------------------
sp\|F1LCL1#1	------------------------LLGIIDFTQ--FG	G	TLKINGTLHGLSP-G-----------------------
sp\|E9J9R9#1	-------------------------------------	-	--------------------------------------
sp\|C3YVA5#1	-------------------------------------	-	--------------------------------------
sp\|Q9XYS0#1	-------------------------------------	-	--------------------------------------
sp\|G5ECR5#1	-------------------------------------	S	FLKLNGSVSGLAA-G-----------------------
sp\|P34461#1	-------------------------------------	S	FLKLNGSVSGLAA-G-----------------------
sp\|A7K8F0#1	---------NTKPIQAI-AVLPGDVSGTVRFVE--EG	K	RVRVDLDIKGLKPNF-----------------------
sp\|A7J6E5#1	------------------------VSGTVRFEE--EG	S	KVKISVDMAGLTPNK-----------------------
sp\|F4WBA7#1	-------------------------------------	-	---VTGTITELNP-G-----------------------
sp\|A8XAB4#1	-------------------------------------	S	FLKLNGSVSGLAA-G-----------------------
sp\|E3LSE9#1	-------------------------------------	S	FLKLNGTVSGLQA-G-----------------------
sp\|A7ITH9#1	------------------------VSGTVRFEE--EG	S	KVKISVDIAGLTPNK-----------------------
sp\|A7UL77#1	------------------------VAGTIVFHHMRGS	T	TIHIEGNVTGLTP-V-----------------------
sp\|Q45Q33#1	------------------------VAGTIVFHHMRGS	T	TIHIEGNVTGLTP-G-----------------------
sp\|C3YDS5#1	-------------------------------------	-	--------------------------------------
sp\|C5H405#1	------ARCEIMPNKEI-TDLAYRVRGHVKLSQKPGQ	D	NISLDYNLRNLIPSH-----------------------
sp\|P51547#1	-----------------------KTVGIIDLVQ--TG	T	LVKMNGSVSGLQP-G-----------------------
sp\|UPI0001925053#1	-------------------------------------	-	---IEGYISGVSP-G-----------------------
sp\|A0S5T9#1	-------------------------------------	-	---IEGYISGVSP-G-----------------------
sp\|E2B222#1	-------------------------------------	-	--------------------------------------
sp\|UPI0000220AB3#1	-------------------------------------	S	FLKLNGSVSGLAA-G-----------------------
sp\|D9I7Q3#1	-------------------------------------	-	---IEGYISGVSP-G-----------------------
sp\|C8XTB0#1	-------------------------------------	-	--------------------------------------
sp\|Q9NB64#1	-------------------------------------	-	--------------------------------------
sp\|E5EQ52#1	---------------------HPNIKGVVEFSEKGNK	V	VIKGMLKSSKFKN-S-----------------------
sp\|A7RX84#1	-------------------------------------	-	-----------PPLT-----------------------
sp\|C1BSR9#1	GVVRSSRNPRTKVTLFK-RGNTSEPIGNIYLME--MN	G	VVILMGNLYRLPP-G-----------------------
sp\|UPI0001CBB879#2	YIYGGCYIRPNPS-GIN-VALRKNIEGIIEIKQKSTG	G	EVEITLDLSGFNTNS-----------------------
sp\|F2Y0Q6#1	--------------------------GIVKFTE--EN	N	EVKIELFLSGLDKNA-----------------------
sp\|D4QFJ5#1	---ALHAHCEVTPNTQT-PGLSYKIRGHIELTQEPHH	D	EVTLKYHLRNMKPHA-----------------------
sp\|D4QFJ4#1	---ALHAHCEVTPNTQT-PGLSYKIRGHIELTQEPHH	D	EVTLKYHLRNMKPHA-----------------------
sp\|D4QFJ6#1	---ALHAHCEVTPNTQT-PGLSYKIRGHIELTQEPHH	D	EVTLKYHLRNMKPHA-----------------------
sp\|C1BQG7#1	-------------------------------------	-	--------------------------------------
sp\|P16026#1	-------------------------------------	-	-----------PPGK-----------------------
sp\|Q5DG63#1	-------------------------------------	-	-----------PRNA-----------------------
sp\|C0CYN1#1	--------------VTG-NSKAPQLSGLVKFYHT-PY	G	GVLVEAEFFGLPNVDREGSSD-----------------
sp\|C1C108#1	-------------------------------------	-	--------------------------------------
sp\|Q5BWZ1#1	-------------------------------------	-	-----------PRNS-----------------------
sp\|E9GVW1#1	--------------AVV-TISNGEINGKIVFEQASLK	S	PVKIRGTIYGLEA-G-----------------------
sp\|G0WPB5#1	-------------------------------------	-	-------LAGFKTDDNIT--------------------
sp\|E9GTP1#1	-------------------------------------	-	--------------------------------------
sp\|F6JYC7#1	-------------------------------------	-	--------------------------------------
sp\|G0Y2K4#1	-------------------------------------	-	--------------------------------------
sp\|UPI0000E80489#1	-------------------------------------	-	--------------------------------------

Shown are 75 amino acids surrounding the mutation position (marked with a black box). An interactive version of the complete alignment is also available.

3D Visualization

PDB/DSSP Snapshot 03-Jan-2012 (78304 Structures)