Human HnRNPA1 non synonymous SNP analysis in Amyotrophic Lateral Sclerosis |
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| Position | Natural Variant | nsSNPAnalyzer | PhD-SNP | Polyphen-2 | SIFT | SNAP | SNPs&GO | Provean | Aggregation Tendency (TANGO) | Amyloid Propensity (WALTZ) | Chaperone Binding Tendency (LIMBO) | Structural Analisys | Natural variant | |||
| 73 | Asn73Ser | Neutral | Neutral | Neutral | Neutral | Neutral | Neutral | Neutral | Not affect | Not affect | Not affect | Structure | N73S | |||
| 314 | Asp314Val | Neutral | Disease | Disease | Disease | Disease | Neutral | Disease | Not affect | Increase | Not affect | Structure | D314V | |||
| 314 | Asp314Asn | Neutral | Neutral | Neutral | Disease | Disease | Neutral | Disease | Not affect | Increase | Not affect | Structure | D314N | |||
| 319 | Asn319Ser | Neutral | Disease | Neutral | Disease | Neutral | Neutral | Neutral | Not affect | Decrease | Not affect | Structure | N319S | |||